Digital technology intensifies the immersion in the diversity of forms of expression of Digital Culture (DC), facilitating its construction and expression. The dynamics demands a Media and Information Literacy (AMI). In this discourse, university research is not absent, on the contrary, it inquiries about its theoretical and conceptual interrelations; its evolution and the fields of knowledge manifested in the Peruvian reality. In this sense, from the systematic review, 35 university theses linked to AMI and CD, and defended between 2016 and 2020, were analyzed, evidencing the dissimilar trajectories, their tangencies and absences, as well as the tenuous interactions. From the meta-synthesis, the spaces of creation of networked cultures were recognized, expressed as challenges and challenges of affirmation of a digital culture, which, although limited by digital divides, express transitions towards enculturation and citizen integration. The scenarios described above make it inevitable that the AMI should give greater impetus to the promotion of digital culture.