Title
Monitoring gait at home with radio waves in Parkinson's disease: A marker of severity, progression, and medication response
Date Issued
21 September 2022
Access level
metadata only access
Resource Type
journal article
Author(s)
Liu Y.
Zhang G.
Tarolli C.G.
Hristov R.
Jensen-Roberts S.
Waddell E.M.
Myers T.L.
Pawlik M.E.
Soto J.M.
Wilson R.M.
Yang Y.
Nordahl T.
Adams J.L.
Schneider R.B.
Kieburtz K.
Ellis T.
Dorsey E.R.
Katabi D.
University of Rochester
Abstract
Parkinson's disease (PD) is the fastest-growing neurological disease in the world. A key challenge in PD is tracking disease severity, progression, and medication response. Existing methods are semisubjective and require visiting the clinic. In this work, we demonstrate an effective approach for assessing PD severity, progression, and medication response at home, in an objective manner. We used a radio device located in the background of the home. The device detected and analyzed the radio waves that bounce off people's bodies and inferred their movements and gait speed. We continuously monitored 50 participants, with and without PD, in their homes for up to 1 year. We collected over 200,000 gait speed measurements. Cross-sectional analysis of the data shows that at-home gait speed strongly correlates with gold-standard PD assessments, as evaluated by the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III subscore and total score. At-home gait speed also provides a more sensitive marker for tracking disease progression over time than the widely used MDS-UPDRS. Further, the monitored gait speed was able to capture symptom fluctuations in response to medications and their impact on patients' daily functioning. Our study shows the feasibility of continuous, objective, sensitive, and passive assessment of PD at home and hence has the potential of improving clinical care and drug clinical trials.
Start page
eadc9669
Volume
14
Issue
663
Language
English
OCDE Knowledge area
Neurología clínica
Neurociencias
Scopus EID
2-s2.0-85138315770
PubMed ID
Source
Science translational medicine
ISSN of the container
1946-6234
Sources of information:
Directorio de Producción Científica
Scopus