The clinicopathologic features of oral crypto- coccosis manifested as multifocal tumor-like lesions located in the upper and lower gingival tissues of a 36-year-old male patient with AIDS are described. The gingival lesions were the initial manifestation of disseminated cryptococ- cosis from which central nervous system involvement was established. Clinical differential diagnosis and histopatho- logic features are discussed. Effect of treatment on the gingival lesions after 18 months follow-up is presented. © Humana 2008.