Title
Effect of pro-inflammatory cytokine stimulation on human breast cancer: Implications of chemokine receptor expression in cancer metastasis
Date Issued
08 October 2009
Access level
metadata only access
Resource Type
research article
Author(s)
Franco-Barraza J.
Silva A.L.E.
Pont G.D.
Soldevila G.
Meza I.
García-Zepeda E.A.
Universidad Nacional Autónoma de México
Abstract
Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-α and IFN-γ on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-α increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments. © 2009 Elsevier Ireland Ltd. All rights reserved.
Start page
176
End page
185
Volume
283
Issue
2
Language
English
OCDE Knowledge area
Oncología
Subjects
Scopus EID
2-s2.0-69849103351
PubMed ID
Source
Cancer Letters
ISSN of the container
03043835
Sponsor(s)
We would like to thank Dr. Guillermo Alfaro (in memoriam) for his valuable support and provide us with cell lines. This work was supported in part by a CONACyT grant to EGZ (58294) and to IM (42724). JVS, JFB (172665), and AES were supported by a Doctoral Fellowship from CONACyT.
Sources of information:
Directorio de Producción Científica
Scopus