The explorations in medical sciences have provided innumerable biomaterials that can perform, augment, or replace the natural function of a defective organ by interacting with the biological system. These materials represent a unique class of biomedical functional materials that potentially perform broad spectrum of biological activities in the absence of the original living tissue/organ, thereby replace the problems encountered with the defective tissue/organ and support smooth functioning of the organ and the living organism. The day-to-day increased demand in the medical field for the bioalternatives that could be able to perform the living activities of bodily organs has raised the interest of the researchers to design novel biomaterials. Hence, the study of biomaterials has become crucial for the material scientists and engineers to understand more about biomaterials. In that point of view, the present chapter focuses on the design, development, and biomedical applications of biomaterials.