Title
Revenant: A database of resurrected proteins
Date Issued
01 January 2020
Access level
open access
Resource Type
journal article
Author(s)
Publisher(s)
Oxford University Press
Abstract
Revenant is a database of resurrected proteins coming from extinct organisms. Currently, it contains a manually curated collection of 84 resurrected proteins derived from bibliographic data. Each protein is extensively annotated, including structural, biochemical and biophysical information. Revenant contains a browse capability designed as a timeline from where the different proteins can be accessed. The oldest Revenant entries are between 4200 and 3500 million years ago, while the younger entries are between 8.8 and 6.3 million years ago. These proteins have been resurrected using computational tools called ancestral sequence reconstruction techniques combined with wet-laboratory synthesis and expression. Resurrected proteins are commonly used, with a noticeable increase during the past years, to explore and test different evolutionary hypotheses such as protein stability, to explore the origin of new functions, to get biochemical insights into past metabolisms and to explore specificity and promiscuous behaviour of ancient proteins.
Volume
2020
Language
English
OCDE Knowledge area
Biotecnología médica
Bioquímica, Biología molecular
Scopus EID
2-s2.0-85084626047
PubMed ID
Source
Database
ISSN of the container
17580463
Sources of information:
Directorio de Producción Científica
Scopus