We present experimental evidence and modeling results which indicate that eastward thermospheric wind is the primary controlling factor of equatorial spread-F initiation in the post-sunset ionosphere. Eastward wind-driven Pedersen currents are able to polarize F-region density perturbations with westward tilting wavefronts into rapidly growing modes to trigger the formation of spread-F bubbles. The described process is so rapid that seeding requirements of spread-F initiation by external factors such as gravity waves are effectively eliminated. © 2007 Elsevier Ltd. All rights reserved.