This research seeks to design a pedagogical strategies proposal for the economic sciences learning at a Faculty of Economics in Colombia; Methods: derived from complex thinking has three phases: resonance, biolearning-relationality and holographic phase. These involve the following examples of pedagogical mediation: flipped classroom, gamification, sociopedagogical cartography, virtual learning objects and Feeling methodology with the pillars of bio-pedagogy, knowledge construction, critical thinking and social transformation; the research shows the achievement of learning objectives in economics in line with the bio-pedagogical vision, using the proposed pedagogical mediation; Linking pedagogical innovations based on biopedagogy, allows improving the academic objectives proposed for the training of economists