Title
Cancer Cells Microsurgery via Asymmetric Bent Surface Au/Ag/Ni Microrobotic Scalpels through a Transversal Rotating Magnetic Field
Date Issued
28 July 2020
Access level
metadata only access
Resource Type
journal article
Author(s)
Vyskočil J.
Jablonská E.
Novotný F.
Ruml T.
Pumera M.
University of Chemistry and Technology
Publisher(s)
American Chemical Society
Abstract
The actuation of micro/nanomachines by means of a magnetic field is a promising fuel-free way to transport cargo in microscale dimensions. This type of movement has been extensively studied for a variety of micro/nanomachine designs, and a special magnetic field configuration results in a near-surface walking. We developed "walking"micromachines which transversally move in a magnetic field, and we used them as microrobotic scalpels to enter and exit an individual cancer cell and cut a small cellular fragment. In these microscalpels, the center of mass lies approximately in the middle of their length. The microrobotic scalpels show good propulsion efficiency and high step-out frequencies of the magnetic field. Au/Ag/Ni microrobotic scalpels controlled by a transversal rotating magnetic field can enter the cytoplasm of cancer cells and also are able to remove a piece of the cytosol while leaving the cytoplasmic membrane intact in a microsurgery-like manner. We believe that this concept can be further developed for potential biological or medical applications.
Start page
8247
End page
8256
Volume
14
Issue
7
Language
English
OCDE Knowledge area
Bioquímica, Biología molecular Oncología
Scopus EID
2-s2.0-85087004011
PubMed ID
Source
ACS Nano
ISSN of the container
19360851
Sponsor(s)
This work was supported by the project Advanced Functional Nanorobots (reg. no. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR).
Sources of information: Directorio de Producción Científica Scopus