Title
Cancer Cells Microsurgery via Asymmetric Bent Surface Au/Ag/Ni Microrobotic Scalpels through a Transversal Rotating Magnetic Field
Date Issued
28 July 2020
Access level
metadata only access
Resource Type
journal article
Author(s)
VyskoÄŤil J.
Jablonská E.
NovotnĂ˝ F.
Ruml T.
Pumera M.
University of Chemistry and Technology
Publisher(s)
American Chemical Society
Abstract
The actuation of micro/nanomachines by means of a magnetic field is a promising fuel-free way to transport cargo in microscale dimensions. This type of movement has been extensively studied for a variety of micro/nanomachine designs, and a special magnetic field configuration results in a near-surface walking. We developed "walking"micromachines which transversally move in a magnetic field, and we used them as microrobotic scalpels to enter and exit an individual cancer cell and cut a small cellular fragment. In these microscalpels, the center of mass lies approximately in the middle of their length. The microrobotic scalpels show good propulsion efficiency and high step-out frequencies of the magnetic field. Au/Ag/Ni microrobotic scalpels controlled by a transversal rotating magnetic field can enter the cytoplasm of cancer cells and also are able to remove a piece of the cytosol while leaving the cytoplasmic membrane intact in a microsurgery-like manner. We believe that this concept can be further developed for potential biological or medical applications.
Start page
8247
End page
8256
Volume
14
Issue
7
Language
English
OCDE Knowledge area
OncologĂ­a BioquĂ­mica, BiologĂ­a molecular
Scopus EID
2-s2.0-85087004011
PubMed ID
Source
ACS Nano
ISSN of the container
19360851
Sponsor(s)
This work was supported by the project Advanced Functional Nanorobots (reg. no. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR).
Sources of information: Directorio de ProducciĂłn CientĂ­fica Scopus