Title
Kinetics and avidity of anti-toxocara antibodies (IgG) in rabbits experimentally infected with toxocara canis
Date Issued
01 January 2016
Access level
open access
Resource Type
journal article
Author(s)
Universidad de SĂŁo Paulo
Publisher(s)
Brazilain Coll Veterinary Parasitology
Abstract
An evaluation was made of the kinetics and avidity of anti-Toxocara antibodies (IgG) in rabbits experimentally infected with embryonated Toxocara canis eggs. Seventeen four month old New Zealand White rabbits were distributed into two groups. In the experimental group, twelve rabbits were infected orally with 1,000 embryonated T. canis eggs. A second group (n = 5), uninfected, was used as a control. Serum samples were collected for analysis on days 7, 14, 21, 28 and 60 post-infection (DPI). An indirect ELISA test was performed to evaluate the reactivity index (RI) of IgG anti-T. canis antibodies and to calculate the avidity index (AI). The animals showed seroconversion from the 14th DPI, with high AI (over 50%) except for one animal, which presented an intermediate AI. At 60 DPI, all the animals were seropositive and maintained a high AI. The data indicated that specific IgG antibodies formed early (14 DPI) in rabbits infected with T. canis, with a high avidity index that persisted throughout the course of the infection.
Start page
99
End page
104
Volume
25
Issue
1
Language
English
OCDE Knowledge area
ParasitologĂa
Enfermedades infecciosas
InmunologĂa
Subjects
Scopus EID
2-s2.0-84961901646
PubMed ID
Source
Revista Brasileira de Parasitologia Veterinaria
ISSN of the container
0103846X
Sources of information:
Directorio de ProducciĂłn CientĂfica
Scopus