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Publication2007 Mutual events within the binary system of (22) Kalliope( 2008-11-01)
;Descamps P. ;Marchis F. ;Pollock J. ;Berthier J. ;Birlan M. ;Vachier F.In 2007, the asteroid Kalliope will reach one of its annual equinoxes. As a consequence, its small satellite Linus orbiting in the equatorial plane will undergo a season of mutual eclipses and occultations very similar to the one that the Galilean satellites undergo every 6 years. This paper is aimed at preparing a campaign of observations of these mutual events occurring from February to May 2007. This opportunity occurs only under favorable geometric conditions when the Sun and/or the Earth are close to the orbital plane of the system. This is the first international campaign devoted to the observation of photometric events within an asynchronous asteroidal binary system. We took advantage of a reliable orbit solution of Linus to predict a series of 24 mutual eclipses and 12 mutual occultations observable in the spring of 2007. Thanks to the brightness of Kalliope (mv ≃ 11), these observations are easy to perform even with a small telescope. Anomalous attenuation events could be observed lasting for about 1-3 h with amplitude up to 0.09 mag. The attenuations are of two distinct types that can clearly be identified as primary and secondary eclipses similar to those that have been previously observed in other minor planet binary systems [Pravec, P., Scheirich, P., Kusnirák, P., Sarounová, L., Mottola, S., Hahn, G., Brown, P., Esquerdo, G., Kaiser, N., Krzeminski, Z., Pray, D.P., Warner, B.D., Harris, A.W., Nolan, M.C., Howell, E.S., Benner, L.A.M., Margot, J.-L., Galád, A., Holliday, W., Hicks, M.D., Krugly, Yu.N., Tholen, D., Whiteley, R., Marchis, F., Degraff, D.R., Grauer, A., Larson, S., Velichko, F.P., Cooney, W.R., Stephens, R., Zhu, J., Kirsch, K., Dyvig, R., Snyder, L., Reddy, V., Moore, S., Gajdos, S., Világi, J., Masi, G., Higgins, D., Funkhouser, G., Knight, B., Slivan, S., Behrend, R., Grenon, M., Burki, G., Roy, R., Demeautis, C., Matter, D., Waelchli, N., Revaz, Y., Klotz, A., Rieugné, M., Thierry, P., Cotrez, V., Brunetto, L., Kober, G., 2006. Photometric survey of binary near-Earth asteroids. Icarus 181, 63-93]. With these favorable circumstances, such photometric observations will provide us tight constraints regarding physical properties of Linus such as the size, shape and synodic spin period. © 2008 Elsevier Ltd. All rights reserved. -
Publication2D and 3D imaging of the relationship between maxillary sinus and posterior teeth(Piracicaba Dental School - UNICAMP, 2015-01-01)
;de Almeida S. ;Ambrosano G.Bóscolo F.Aim: To compare the qualitative and quantitative information yielded by imaging modalities on the evaluation of the relationship between the maxillary sinus and the apices of posterior teeth. Methods: Three oral radiologists examined 109 panoramic radiographs and cone-beam computed tomography (CBCT) images obtained from a digital archive. A total of 1,875 apices were classified according to their topographic relationship in both imaging modalities. Agreements between the two imaging techniques were examined statistically. The evaluation was repeated in 25% of the sample to statistically evaluate the intraobserver agreement, with a 30-day interval. Results: The values found in the Kappa test for qualitative assessment and the intraclass correlation coefficient (ICC) for quantitative assessment showed nearly perfect and excellent correlation, respectively. Regarding the correlation between the two images, the Kappa test in the quality assessment showed a slight correlation between the palatal roots of the right first molars and second molars. Moreover, the quantitative evaluation by ICC showed poor agreement for the palatal roots of the left first molar and second molar, as well as for the buccomesial of the right second molars and for the buccodistal of the left second molars. Conclusions: There is low correlation between panoramic radiography and CBCT when roots are in contact or above the maxillary sinus floor. A high level of agreement was observed when roots are below the maxillary sinus floor. -
Publication2D–3D comparison of the temporomandibular joint in skeletal Class II versus Class I adults: A retrospective study(Elsevier Masson s.r.l., 2020)
;García-Díaz R. ;Agudelo-Botero A.M.Fiori-Chincaro G.A.Objective: To compare the temporomandibular joint (TMJ) morphological characteristics in people with Class II versus Class I sagittal skeletal relationship and to identify other factors that influence the TMJ dimensions. Material and methods: This cross-sectional and retrospective study evaluated 188 people divided into two groups, 92 cone-beam computed tomographies (CBCTs) and lateral radiographs (LR) of people with Skeletal class II relationship with Class II division 1 malocclusion versus 96 CBCTs and LR of people with Class I skeletal relationship and Class I malocclusion (controls). The CBCTs included people of both sexes, aged between 15 and 65 years old. The 3D Imaging Carestream Software was used to evaluate the condyle height and neck width, mediolateral and anteroposterior condyle dimensions, the shape of the glenoid fossa and condyle in the CBCTs. Likewise, the ANB angle, the Wits appraisal and other measurements were evaluated on LR. Besides, Mann-Whitney U, Chi2 and multiple linear regression tests were performed. The significance level was set at P ˂ 0.05. Results: The mediolateral and anteroposterior condyle dimensions were smaller in class II people (1.82 mm and 0.29 mm, respectively) than class I people (P < 0.05). Likewise, height and neck width of condyle were smaller in class II people (0.73 mm and 0.40 mm, respectively) than class I people (P < 0.05). Multiple linear regression identified mainly the ANB angle as a factor (P < 0.05) that influenced the dimensions, decreasing the condyle dimensions in skeletal class II relationship. Conclusions: People with skeletal class II relationship showed smaller condyle dimension values than class I people. A decrease in the dimensions of the eminence and the condyle could be expected when the ANB angle increases. -
Publication3-[4-(4-nitrophenil)piperazin-1-il]-2-quinoxalinecarbonitrile derivatives as antileucemic agents( 1998-12-01)
;Sainz Y. ;Ortega M. ;Lopez de Cerain A.Monge A.Quinoxaline derivatives are compounds that show a great spectrum of biological activities and offer a great variety of possibilities for its structural modification. We can detail quinoxaline 1,4-di-oxides as new anticancer compounds against hypoxic cells. Now, we report the synthesis of new derivatives, 3-[4-(4-nitrofenil)piperazin-1-il]-2-quinoxalinecarbonitriles. These compounds are cellular growing inhibitors especially over leucemia celular panel. -
Publication3D characterization and localization of anatomical landmarks of the footThe anatomical landmarks on the body surface are important to shape and motion analysis. This paper presents a method for extracting anatomical landmarks on the foot from scattered 3D surface points collected by FastSCAN (Polhemus, Colchester, Vermont, USA). By least squares surface fitting, the surface is reconstructed from the scattered points and the Gaussian curvature and mean curvature are calculated. The landmarks formed by underlying muscles and skeletal structures distinguish themselves clearly on the Koenderink shape index maps. The loci of landmarks avail further analysis such as the arch height and tibial torsion.
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Publication4-Ary CSK Modulation Scheme Better than RGBW for LCD-Screen Camera CommunicationsThe extended adoption of portable computing equipment allows cheap and effortless access a screen and a camera, which can be exploited to suggest a wireless optical communications structure for specific applications. However, it faces low data rate performance because of the camera and screen physical limitations. Color shift keying (CSK) arises as a modulation alternative to circumvent this problem and the particular case of 4-Ary CSK is addressed in this paper. We focus our attention on how machines perceive color and identify two 4-Ary sets of equidistant colors employing communications theory. We emphasize the use of a LCD screen as a transmitter and an off-The-shelf smartphone camera as a receiver. Our results show that color set formed by aqua, fuchsia, yellow and black outperforms the color set comprising red (R), green (G), blue (B) and white (W) in a 4-CSK modulation scheme. In addition, we found that the mean value of the received pixels color components is adequate for detection when a LCD screen is the transmitter. Moreover, we identify some optical distortions that degrade the system performance when distance between transmitter and receiver is 18.2 cm.
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Publication4′-Hydroxy-6,7-methylenedioxy-3-methoxyflavone: A novel flavonoid from Dulacia egleri with potential inhibitory activity against cathepsins B and L(Elsevier B.V., 2019-01-01)
;de Novais L.M.R. ;de Arueira C.C.O. ;Ferreira L.F. ;Ribeiro T.A.N. ;Sousa P.T. ;Jacinto M.J. ;de Carvalho M.G. ;Judice W.A.S. ;Jesus L.O.P. ;de Souza A.A. ;Torquato H.F.V.Silva V.C.A new flavone, 4′-hydroxy-6,7-methylenedioxy-3-methoxyflavone 1, and two other nucleosides, ribavirin 2 and adenosine 3, were isolated from the leaves of Dulacia egleri. The nucleosides were identified by spectroscopic techniques (1D, 2D-NMR) while the structure of the flavonoid was established by 1D, 2D-NMR analysis, including HRESIMS data. The results obtained in the biological assays showed that the compound 1 was able to inhibit cathepsins B and L with IC50 of 14.88 ± 0.18 μM and 3.19 ± 0.07 μM, respectively. The mechanism of inhibition for both enzymes were determined showing to be competitive at cathepsin B with Ki = 12.8 ± 0.6 μM and non-linear non-competitive with positive cooperativity inhibition at cathepsin L with Ki = 322 ± 33 μM, αKi = 133 ± 15 μM, βKi = 5.14 ± 0.41 μM and γKi = 13.2 ± 13 μM. -
Publication74-year-old woman with intermittent fever, headache, and strokeEpisodic fever of unknown origin and constitutional symptoms for 2 years in an elderly woman prompted investigation for a causative factor.
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PublicationA 12-year retrospective review of bullous systemic lupus erythematosus in cutaneous and systemic lupus erythematosus patients(SAGE Publications Ltd, 2018-09-01)
;Pons-Estel G.J. ;Quintana R. ;Sacnún M.Pons-Estel B.A. -
PublicationA 3D assessment tool for accurate volume measurement for monitoring the evolution of cutaneous Leishmaniasis woundsClinical assessment and outcome metrics are serious weaknesses identified on the systematic reviews of cutaneous Leishmaniasis wounds. Methods with high accuracy and low-variability are required to standarize study outcomes in clinical trials. This work presents a precise, complete and noncontact 3D assessment tool for monitoring the evolution of cutaneous Leishmaniasis (CL) wounds based on a 3D laser scanner and computer vision algorithms. A 3D mesh of the wound is obtained by a commercial 3D laser scanner. Then, a semi-automatic segmentation using active contours is performed to separate the ulcer from the healthy skin. Finally, metrics of volume, area, perimeter and depth are obtained from the mesh. Traditional manual 3D and 3D measurements are obtained as a gold standard. Experiments applied to phantoms and real CL wounds suggest that the proposed 3D assessment tool provides higher accuracy (error <2%) and precision rates (error <4%) than conventional manual methods (precision error < 35%). This 3D assessment tool provides high accuracy metrics which deserve more formal prospective study. © 2012 IEEE.
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PublicationA 4-week ciinical comparison of an oscillating-rotating power brush versus a marketed sonic brush in reducing dental plaque(Mosher and Linder, Inc, 2014-01-01)
;Büchel B. ;Reise M. ;Klukowska M. ;Grender J. ;Timm H.Sigusch B.W.To assess the plaque removal efficacy of an oscillating-rotating power brush relative to a newly- introduced sonic power brush. Methods: This study used a randomized, examiner-blind, single-center, two-treatment, parallel group 4-week design. Subjects with pre-existing plaque scores of at least 1.75 on the Turesky Modification of the Quigley-Hein Plaque Index (TMQHPI) were evaluated for baseline whole mouth and approximal plaque scores. They received either the oscillating-rotating brush (Oral-B Professional Care 1000, sold as Oral-B Professional Care 600 in some regions, with the Oral-B Precision Clean brush head, D16u/EB2O) or the sonic brush (Colgate ProClinical C200 with Colgate Triple Clean brush head) and brushed twice-daily with the assigned brush and a standard fluoride dentifrice for 4 weeks before returning for plaque measurements. Prior to baseline and the Week 4 measurements, participants abstained from oral hygiene for 12 hours and from eating, chewing gum and drinking for 4 hours. Results: A total of 131 subjects were enrolled in the study at baseline, with all completing the study: 65 in the oscillating-rotating group, and 66 in the sonic group. Both brushes significantly reduced plaque over the 4-week study period. The oscillating-rotating brush was statistically significantly more effective in reducing plaque (P< 0.001) than the sonic brush. Compared to the sonic power brush, the adjusted mean plaque reduction scores for the oscillating-rotating power brush were more than five times greater for whole mouth and approximal areas. -
PublicationA 56-year-old Man from Peru with Prolonged Fever and Severe Anaemia: Bartonellosis - Oroya Fever and Verruga Peruana(Elsevier Ltd, 2015-01-01)
;Jacquerioz F. -
PublicationA benchmarking approach to track and compare administrative charges on flow and balance in individual account pension systemsThis article studies the effects on individual welfare caused by administrative charges or fees on balance (assets) and flow (contributions) during the accumulation phase of a defined-contribution (DC) pension plan under the system of individual retirement accounts (IA). Assuming a complete financial market and suitable deterministic functions to model contributions and administrative charges, we are able to contrast the optimal expected utility of terminal wealth generated under both charge schemes. In this framework, we also derive closed-form expressions to determine equivalent administrative charges, that is, the precise level of charges on flow and balance that makes them indifferent to the risk-averse participant. These expressions are independent of the market price of risk, the risky asset's volatility and the participant's utility function. Furthermore, our methodology can be helpful for regulators and policy makers aiming to dynamically track the future evolution of administrative charges or to fairly compare costs across DC pension systems, especially those operating under charge on flow.
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PublicationA bicriteria approach identifying nondominated portfolios(Hindawi Publishing Corporation, 2014-01-01)
;Pereira J. ;Crawford B. ;Paredes F.We explore a portfolio constructive model, formulated in terms of satisfaction of a given set of technical requirements, with the minimum number of projects and minimum redundancy. An algorithm issued from robust portfolio modeling is adapted to a vector model, modifying the dominance condition as convenient, in order to find the set of nondominated portfolios, as solutions of a bicriteria integer linear programming problem. In order to improve the former algorithm, a process finding an optimal solution of a monocriteria version of this problem is proposed, which is further used as a first feasible solution aiding to find nondominated solutions more rapidly. Next, a sorting process is applied on the input data or information matrix, which is intended to prune nonfeasible solutions early in the constructive algorithm. Numerical examples show that the optimization and sorting processes both improve computational efficiency of the original algorithm. Their limits are also shown on certain complex instances. © 2014 Javier Pereira et al. -
PublicationA binary cuckoo search algorithm for solving the set covering problem(Springer Verlag, 2015-01-01)
;Crawford B. ;Olivares R. ;Barraza J. ;Johnson F.Paredes F.The non-unicost set covering problem is a classical optimization benchmark that belongs to the Karp’s 21 NP-complete problems. In this paper, we present a new approach based on cuckoo search for solving such problem. Cuckoo search is a modern nature-inspired metaheuristic that has attracted much attention due to its rapid convergence and easy implementation. We illustrate interesting experimental results where the proposed cuckoo search algorithm reaches several global optimums for the non-unicost instances from the OR-Library. -
PublicationA bioinformatics study of structural perturbation of 3CL-protease and the HR2-domain of SARS-CoV-2 induced by synergistic interaction with ivermectins(AMG Transcend Association, 2021-01-01)
;González-Paz L.A. ;Lossada C.A. ;Moncayo L.S. ;Romero F. ;Vera-Villalobos J. ;Pérez A.E. ;Portillo E. ;San-Blas E.Alvarado Y.J.The pandemic caused by SARS-CoV-2 forces drug research to combat it. Ivermectin, an FDA approved antiparasitic drug formulated as a mixture 80:20 of the equipotent homologous 22,23 dihydro ivermectin (B1_a and B1_b), which is known to inhibit SARS-CoV-2 in vitro with a mechanism of action to be defined. It draws attention powerfully that the energetic and structural perturbation that this drug induces by binding on SARS-COV-2 proteins of importance for its proliferation is ill unknown. Hence what we do an exhaustive computational biophysics study to discriminate the best docking of ivermectins to viral proteins and, subsequently, to analyze possible structural alterations with molecular dynamics. The results suggested that ivermectins are capable of docking to the superficial and internal pocket of the 3CL-protease and the HR2-domain, inducing unfolding/folding that change the native conformation in these proteins. In particular, ivermectin binds to the 3CL protease and leads this protein to an unfolded state, whereas the HR2-domain to a more compact conformation in comparison to the native state by refolding when the drug binding to this protein. The results obtained suggest a possible synergistic inhibitory against SARS-COV-2 owing to each role of ivermectins when favorably binding to these viral proteins. Given the importance of the results obtained about this new mechanism of action of ivermectin on SARS-CoV-2, experimental studies are needed that corroborate this proposal. -
PublicationA biometric method based on the matching of dilated and skeletonized Ir images of the veins map of the dorsum of the handThis work proposes a biometric identification system that works together with a palm vein reader sensor and a hand-clenching support, designed to perform the capture the back of the hand. Several processing steps were performed: extraction of the region of interest, binarization, dilation, noise filtering, skeletonization, as well as extraction and verification of patterns based on the measurment of coincidence of vertical and horizontal displacements of skeletonized and dilated images. The proposed method achieved the following results: processing time post capture of 1.8 seconds, FRR of 0.47% and FAR of 0,00%, with a referential database of 50 people from a total of 1500 random captures.
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PublicationA bit of basic, a bit of applied? R&D strategies and firm performanceMost studies analysing the relationship between R&D and firm growth focus on total R&D investment. This paper aims to analyse separately each component of R&D investment (basic research, applied research and technological development) and evaluate how these types of R&D investment are related to firm growth. Using a sample of 3972 Spanish manufacturing firms during 2004–2015, our empirical results are the following. First, firms have heterogeneous R&D strategies. The common wisdom that young firms invest in basic research, while old firms invest in applied research, is not supported in our data. Second, we investigate the characteristics and dynamics of firms with different R&D strategies. We observe complementarities between applied research and technological development due to their positive associations with firm growth. Finally, our results show that there is a tendency for firms to transition from basic research to applied research.
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PublicationA block-based variational elasto-damage model for masonry analysis inspired from granular micromechanics: Preliminary studyWe develop a new block-based elasto-damage model for describing masonry structures. The constitutive elastic and damage behavioural laws used within the proposed approach are inspired from those employed in the recent literature in granular micromechanics. Adaptations have been made in many respects, notably the inclusion of impenetrability constraints through energy barriers. The analysis carried out in this paper proves that realistic masonry deformation modes can be obtained.